Acetazolamide and Sodium Bicarbonate in Treatment of Salicylate Poisoning in Adults

The phosphaturic effect of sodium bicarbonate and acetazolamide in dogs.

Urinary inorganic phosphate excretion was studied before and during the administration of sodium bicarbonate and acetazolamide in dogs that were not given infusions of phosphate. The excretion fraction of filtered phosphate increased after sodium bicarbonate or acetazolamide was given. This phosphaturia was attributed to decreased tubular reabsorption of phosphate consequent to alkalinization o...

Acidaemia and salicylate poisoning in adults.

A review of the arterial acid-base status on admission to hospital of 62 adults with severe salicylate poisoning showed that arterial pH was normal or high in most patients, but low in 8. The mean plasma salicylate concentrations of the acidaemic and nonacidaemic patients were similar and the difference in arterial pH was associated with a marked fall in standard bicarbonate in the former group...

Accidental methyl salicylate poisoning in two adults.

Methyl salicylate (MS) is widely available as a component in many over-the-counter brands of ointments, lotions, liniments and medicated oils intended for topical application [1]. Among the most potent forms of methyl salicylate is oil of wintergreen (98% MS). Salicylate ointment has a very high concentration of MS. One teaspoon contains 7000 mg MS, equivalent to 90 baby aspirin tablets.We repo...

The excretion of salicylate in salicylate poisoning.

1. The renal clearance of salicylate has been measured in two groups of patients undergoing treatment by alkaline diuresis for salicylate poisoning. One group received mannitol and sodium lactate, the other acetazolamide and sodium bicarbonate. 2. The relationship between urine pH and salicylate clearance was found to be the same in both groups and similar to that shown at non-toxic concentrati...

Plasma salicylate levels in acute poisoning in adults.